Psoriasis is a chronic autoimmune disease affecting millions worldwide.^[1] The immune system mistakenly targets healthy skin cells, resulting in rapid keratinocyte proliferation and the development of thick, red, scaly, inflamed, and itchy plaques that may affect localized areas or extensive body surfaces. Globally, psoriasis affects approximately 125 million people, including an estimated 3.59 million individuals in India. The disease arises from a complex interaction between genetic susceptibility, immune activation, keratinocyte dysfunction, angiogenesis, oxidative stress, and environmental triggers. Key cytokines, including TNF-α, IL-23, IL-17A, and IL-22, drive chronic inflammation through dysregulated pathways such as JAK/STAT and NF-κB, leading to epidermal hyperproliferation and plaque formation.^[2] Beyond physical symptoms, psoriasis significantly impairs quality of life through persistent itching, discomfort, visible skin lesions, emotional distress, and social stigma. Effective management focuses on the Triad of Relief: Immune Modulation, targeting the systemic cytokine cascade in deep dermal tissues; Deep Hydration, restoring the stratum corneum lipid matrix from the bottom up; and Barrier Repair, replenishing filaggrin and ceramides to reduce transepidermal water loss (TEWL) and strengthen skin barrier function.